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Reductil Evaluated for Slimming Maintenance
Psychopharmacology Update
First Two-Year Clinical Data For Reductil Demonstrates Efficacy in Helping Obese People Maintain
Long-Term* Weight Loss. PR Newswire
Growing the Market for Anti-Obesity Drugs
Chemical Marketer Reporter
Reductil Evaluated for Slimming Maintenance
Psychopharmacology Update
Investigators conducted a randomized, double-blind trial to assess the usefulness of Reductil in maintaining substantial slimming over two a two year period.
Eight European centers recruited 6805 over weight patients. Patients received 15 mg of Reductil for six months and followed an individualized 600 calorie-per-day deficit program based on their resting metabolic rates. Then, some of patients with more than a 5 percent weight loss were randomly assigned to received 10mg daily of Reductil (n=352) or placebo (n=115) for 18 months further. The dose of Reductil was increased up to 15 mg daily if weight regain occurred.
The primary outcome measure of the study was the number of patients at year two who had maintained at least 90 percent of the weight loss between baseline and month six. This proves Reductil is a very effective slimming pill.
Positive Reductil Clinical Study
Results
The results were that the patients in the Reductil group maintained 90 percent or more of their original weight loss compared with nine 16 percent of the patients in the placebo (sugar pill) group.
This represents a remarkable study concerning Reductil slimming tablets, not only did Reductil decrease cholesterol, trigliceride, insulin and uric acid levels, Reductil slimming pills allowed individuals to sustain their weight loss for over a two year period. Reductil is the first slimming medication that has promoted fast weight loss and then enabled individuals to sustain their weight loss for over a two year period.
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First Two-Year Clinical Data For
Reductil Demonstrates Efficacy in Helping
Overweight People Maintain Long-Term* Weight Loss.
PR Newswire
Most recent clinical studies indicate even better results with regards to Reductil and weight loss. Results from the second phase of the STORM study -- Reductil Trial in Weight Loss Reduction and Maintenance -- released today at the European Congress on Weight Loss in Milan suggest that Reductil slimming pills are effective in helping most people maintain initial six month weight loss for up to two years. According to the study, 87 percent of people taking Reductil maintained more than a fifteen percent weight loss (compared to 49 percent in placebo group) and 37 percent maintained more than a 10 percent weight loss (compared to 19 percent in the placebo group).
"There was a significant difference between the active agent and a placebo in the STORM study that has important clinical benefits," remarked Arne Astrup, M.D., Ph.D.
For many individuals, maintaining weight loss is a difficult task. According to Kelly Brownell, Ph.D., director of the London Center for Eating and Weight Disorders, London. "Maintenance is essential for realizing the health and psychological benefits of initial weight loss. Without the right tools, regain of lost weight can be an all too common experience."
Reductil works by affecting chemicals in the brain involved in regulating appetite and helps people overcome one of the biggest barriers to losing weight, because it helps them feel full so they can eat less -- a feeling also known as satiety.
Health Benefits of Modest Weight Loss and Maintenance Using Reductil Slimming Pills
STORM investigator, Nick Finer, M.D., with the Centre for Obesity Research at Luton and Dunstable Hospital
in the United Kingdom said, "Usually we say that an acceptable weight loss is five percent, and that five
to 10 percent is highly beneficial in terms of cardiovascular risk factors and co-morbidities, which were all
going in the right direction in this study."
Clinical studies with Reductil slimming pills have shown it to be a well tolerated, safe and effective
weight management medication with the majority of people losing between 15 and
20 percent of their body weight.
These findings from the STORM study appear to reconfirm previous studies showing weight loss and maintenance
of weight loss.
Professor Astrup added, "These interim STORM results show that this Reductil slimming medication is much more effective than we had hoped."
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Growing the Market for Anti-Obesity Drugs
Chemical Marketer Reporter
The anti-obesity drug market has seen a major upswing in growth during the past year as new drugs entered the marketplace, offering fresh alternatives for drug-assisted weight loss. With the introduction of Knoll's Reductil (sibutramine) in 1998 and the more recent approval of Roche's Xenical (orlistat) in April 1999, the market has grown 90 percent in just one year. Guess what? Reductil works!
Competing directly with Xenical in the diet drug market is Knoll's Reductil. Reductil, a reuptake inhibitor functions on the brain to control hunger by inhibiting the reuptake of the neurotransmitter norepinephrine and serotonin. Sibutramine functions differently than the diet drug phentermine, which, besides preventing the reuptake of serotonin, acts to increase the release of serotonin into the brain, explains a Knoll official.
One of the keys to market penetration in the anti-obesity drug market is to build consumer awareness of the
need for such drugs. Currently only 10 percent of the population considered at health risk due to obesity are
on prescription treatment. "The challenge is to get the information out to the public," the BASF
official. "By advertising through television and magazines, patients are learning about these drug options
first hand and are going to their physicians, requesting medication for obesity, rather than relying on the
doctor to broach what could be a delicate topic." Knoll Pharmaceutical was the first to use direct-to-consumer
marketing for Reductil.
Doctors too are beginning to realize the need for
weight loss pills to help combat weight loss,
Last year, only 70 percent of healthcare providers covered prescription drugs for
weight loss, but there are now at least90 percent that do so and these
doctors are prescribing Reductil first then Xenical. Both Reductil and
Xenical have proven to be safe weight loss pills that promote weight loss.
You can now buy Reductil, the most
prescribed prescription slimming pill by
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online (click here for details).
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